Reading Your Cards

Men and numbers, what a relationship! After my talk on male infertility at the Fertility Planit Show this weekend, I was struck by the numbers of questions asked about the semen analysis. Although very important to me, interest in the other 3 components of the male infertility evaluation, the personal history, physical exam and hormone findings, were all trumped by the sperm count. What do the numbers on a semen analysis really mean?

Speaking in Context

The semen analysis should be read in context of the individual. Within this framework, this is what comes to mind:

  • Ejaculation is a biologic process, kind of like a sneeze, that was never meant to be analyzed, counted, or ordered. But, we do it anyway.
  • There is great daily, weekly and seasonal variability in the results.
  • In and of itself, except when zero, the semen analysis is not a great measure of actual fertility.

Breaking It Down

Here is my loosely structured, high-level view of each of the 4 main variables typically found on a semen analysis.

  • Volume. This is total amount of fluid in the sample. It arises from 3 sources and varies widely with ejaculation frequency. However, when it is low (below 1.5-2mL) you can hang your hat that something is up. The causes of low ejaculate volume are: collection error, retrograde ejaculation, missing vas deferens, ejaculatory duct obstruction or low testosterone.
  • Sperm Count. This is really a “concentration” of sperm number per unit of fluid. When it is high, I typically don’t worry about it. But when it is low, I do. To me, the sperm count is the closest thing we have to a “biomarker” of a man’s overall health as it is influenced by lifestyle issues (alcohol, hot tubs, obesity, diet, disease, fevers, stress, medications, to name a few), findings on exam (varicocele, epididymitis, blockage) or genetic issues (Y-chromosome microdeletions, chromosome counts).
  • Sperm Motility. This is the proportion of sperm that actually move in the sample. And remember, moving sperm do all of the work. Therefore, this variable has the strongest association with actual fertility. To me, sperm motility is a more sensitive indicator of insults to the body than is the sperm count. It also responds more rapidly to corrections than does the sperm count. The same issues that affect sperm count can also affect motility, but they affect motility at lower doses. Other conditions, such as antisperm antibodies or immotile cilia syndromes, only affect sperm motility.
  • Morphology. This is an actuarial analysis of sperm shape. It is a tedious and time-consuming assessment of sperm anatomy that is said to reflect on their “fertilizability” at IVF. However, it is complex enough to make it difficult to standardize well across labs and even among individual technicians. In addition, sperm shape in general has nothing to do with the quality of its genetic payload. Therefore it has little to no clinical value in predicting a successful pregnancy at-home or with assisted reproduction. To me, a low sperm morphology suggests that the “factory” (testicle) is overheated or somehow impaired and that the product (sperm) that is made has crooked headlights or a bad paint job. As a doctor, it encourages me to focus more on issues with the individual and his “factory.”

So that’s my 30,000 foot view of the semen analysis. It’s not really the number of cards you hold as much as it is the quality of the cards and the person who holds them. Words of advice: you may in fact be “holding all of the cards” but they are being “lost in the shuffle.” The cards may not be “stacked against you” but you just need to “play your cards right.”

One thought on “Reading Your Cards

  1. This problem is more coommn than you can imagine in America today. In fact, there are 17% of American males that cannot reproduce due to the low sperm count issue. World health experts are blaming chlorine, fluorine, and dioxin as the cause. In 1940, the sperm count in males was about 166 million per ml. in 1990, just 50 years later, the count has reduced to 66 million per ml. The trend is downward in a straight line. It is now predicted that by 2050, there will be ZERO sperm count in males. By 2015 to 2020, the count is expected to reach the critical mass of 5 million sperm per ml. The world health organization claims we need 20 million sperm to properly fertilize an egg in normal fertilization. However, the 5 million sperm is the minimum estimated.The best thing you can do is to improve your health by seeing a Certified Nutritional Therapist that can test you and preferably one that knows how to do QRA testing. They can test you for specific nutritional deficiencies and not do a bunch of guessing. They can also recommend diets and supplements that will help you. Doctors are not trained to do this. They look for symptoms, create a diagnosis of disease and then recommend drugs and surgery. That is not what you need here. It’s not easy to be healthy in America today.EDIT: The other person posting an answer is correct in the affect of SOY. Fermented soy like the Japanese eat does not have this problem, but the SOY being put into many foods and being promoted as healthy in America is junk and the Soy industry should be put out of business for promoting misinformation and citing studies that are funded by promoters with an agenda.good luck to you

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